α6β1 and α7β1 integrins are required in Schwann cells to sort axons.

@article{Pellegatta201361A,
  title={α6β1 and α7β1 integrins are required in Schwann cells to sort axons.},
  author={Marta Pellegatta and Ad{\`e}le De Arcangelis and Alessandra D'Urso and Alessandro Nodari and Desir{\'e}e Zambroni and Monica Ghidinelli and Vittoria Matafora and Courtney L. Williamson and Elisabeth Georges-Labouesse and Jordan A. Kreidberg and Ulrike Mayer and Karen K McKee and Peter D Yurchenco and Angelo Quattrini and Lawrence Wrabetz and Maria Laura Feltri},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2013},
  volume={33 46},
  pages={17995-8007}
}
During development, Schwann cells extend lamellipodia-like processes to segregate large- and small-caliber axons during the process of radial sorting. Radial sorting is a prerequisite for myelination and is arrested in human neuropathies because of laminin deficiency. Experiments in mice using targeted mutagenesis have confirmed that laminins 211, 411, and receptors containing the β1 integrin subunit are required for radial sorting; however, which of the 11 α integrins that can pair with β1… CONTINUE READING