α3Na+/K+-ATPase Is a Neuronal Receptor for Agrin

@article{Hilgenberg20063NaKATPaseIA,
  title={α3Na+/K+-ATPase Is a Neuronal Receptor for Agrin},
  author={Lutz G.W. Hilgenberg and Hailing Su and Huaiyu Gu and Diane K. O'Dowd and Martin A. Smith},
  journal={Cell},
  year={2006},
  volume={125},
  pages={359-369}
}
Agrin, through its interaction with the receptor tyrosine kinase MuSK, mediates accumulation of acetylcholine receptors (AChR) at the developing neuromuscular junction. Agrin has also been implicated in several functions in brain. However, the mechanism by which agrin exerts its effects in neural tissue is unknown. Here we present biochemical evidence that agrin binds to the alpha3 subunit of the Na+/K+-ATPase (NKA) in CNS neurons. Colocalization with agrin binding sites at synapses supports… CONTINUE READING