α3β1 Integrin Is Required for Normal Development of the Epidermal Basement Membrane

@article{DiPersio199731II,
  title={α3β1 Integrin Is Required for Normal Development of the Epidermal Basement Membrane},
  author={C Michael DiPersio and Kairbaan M Hodivala-Dilke and Rudolf Jaenisch and Jordan A. Kreidberg and Richard O Hynes},
  journal={The Journal of Cell Biology},
  year={1997},
  volume={137},
  pages={729 - 742}
}
Integrins alpha3beta1 and alpha6beta4 are abundant receptors on keratinocytes for laminin-5, a major component of the basement membrane between the epidermis and the dermis in skin. These integrins are recruited to distinct adhesion structures within keratinocytes; alpha6beta4 is present in hemidesmosomes, while alpha3beta1 is recruited into focal contacts in cultured cells. To determine whether differences in localization reflect distinct functions of these integrins in the epidermis, we… CONTINUE READING