α3(V) collagen is critical for glucose homeostasis in mice due to effects in pancreatic islets and peripheral tissues.

@article{Huang20113VCI,
  title={α3(V) collagen is critical for glucose homeostasis in mice due to effects in pancreatic islets and peripheral tissues.},
  author={Guorui Huang and Gaoxiang Ge and Dingyan Wang and Bagavathi Gopalakrishnan and Delana Hopkins Butz and Ricki J Colman and Andras Nagy and Daniel S. Greenspan},
  journal={The Journal of clinical investigation},
  year={2011},
  volume={121 2},
  pages={769-83}
}
Collagen V, broadly expressed as α1(V)2 α2(V) heterotrimers that regulate collagen fibril geometry and strength, also occurs in some tissues, such as white adipose tissue (WAT), pancreatic islets, and skeletal muscle, as the poorly characterized α1(V) α2(V) α3(V) heterotrimer. Here, we investigate the role of α3(V) collagen chains by generating mice with a null allele of the α3(V) gene Col5a3 (Col5a3–/– mice). Female Col5a3–/– mice had reduced dermal fat and were resistant to high-fat diet… CONTINUE READING
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