α2-HS Glycoprotein/Fetuin, a Transforming Growth Factor-β/Bone Morphogenetic Protein Antagonist, Regulates Postnatal Bone Growth and Remodeling

@inproceedings{Szweras20022HSGA,
  title={α2-HS Glycoprotein/Fetuin, a Transforming Growth Factor-β/Bone Morphogenetic Protein Antagonist, Regulates Postnatal Bone Growth and Remodeling},
  author={Melanie Szweras and Danmei Liu and Emily A. Partridge and Judy Pawling and Balram Sukhu and Cameron Clokie and Willi Jahnen-Dechent and Howard C. Tenenbaum and Carol J Swallow and Marc D. Grynpas and J. W. Dennis},
  year={2002}
}
Abstract Soluble transforming growth factor-β (TGF-β)/bone morphogenetic protein (BMP)-binding proteins are widely distributed in mammalian tissues and control cytokine access to membrane signaling receptors. The serum and bone-resident glycoprotein α2-HS-glycoprotein/fetuin (ASHG) binds to TGF-β/BMP cytokines and blocks TGF-β1 binding to cell surface receptors. Therefore, we examined bone growth and remodeling phenotypes in ASHG-deficient mice. The skeletal structure of Ahsg−/− mice appeared… CONTINUE READING

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