α2-HS Glycoprotein/Fetuin, a Transforming Growth Factor-β/Bone Morphogenetic Protein Antagonist, Regulates Postnatal Bone Growth and Remodeling*

@article{Szweras20022HSGA,
  title={α2-HS Glycoprotein/Fetuin, a Transforming Growth Factor-β/Bone Morphogenetic Protein Antagonist, Regulates Postnatal Bone Growth and Remodeling*},
  author={M. Szweras and D. Liu and E. Partridge and J. Pawling and B. Sukhu and C. Clokie and Willi Jahnen-Dechent and Howard C. Tenenbaum and C. Swallow and M. Grynpas and J. Dennis},
  journal={The Journal of Biological Chemistry},
  year={2002},
  volume={277},
  pages={19991 - 19997}
}
Soluble transforming growth factor-β (TGF-β)/bone morphogenetic protein (BMP)-binding proteins are widely distributed in mammalian tissues and control cytokine access to membrane signaling receptors. The serum and bone-resident glycoprotein α2-HS-glycoprotein/fetuin (ASHG) binds to TGF-β/BMP cytokines and blocks TGF-β1 binding to cell surface receptors. Therefore, we examined bone growth and remodeling phenotypes in ASHG-deficient mice. The skeletal structure of Ahsg−/− mice appeared normal at… Expand
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References

SHOWING 1-10 OF 51 REFERENCES
Concentration of Transforming Growth Factor Beta in Human Bone Tissue: Relationship to Age, Menopause, Bone Turnover, and Bone Volume
  • J. Pfeilschifter, I. Diel, +9 authors R. Ziegler
  • Biology, Medicine
  • Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
  • 1998
  • 84
Regulation of Osteogenesis by Fetuin*
  • 126
  • PDF
Bone morphogenetic protein-3 is a negative regulator of bone density
  • 380
Increased expression of TGF-beta 2 in osteoblasts results in an osteoporosis-like phenotype
  • 346
  • PDF
...
1
2
3
4
5
...