α2-Adrenoceptors modulating insulin release from isolated pancreatic islets

@article{Nakaki20042AdrenoceptorsMI,
  title={$\alpha$2-Adrenoceptors modulating insulin release from isolated pancreatic islets},
  author={Toshio Nakaki and Teruo Nakadate and Ryuichi Kato},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={2004},
  volume={313},
  pages={151-153}
}
SummaryUsing rat isolated pancreatic islets, we investigated the effects of various α-adrenoceptor blocking agents on adrenaline-induced inhibition of glucose-stimulated insulin release. Yohimbine was about 100 times more potent than prazosin in antagonizing the inhibitory effect of adrenaline. At concentrations of 10 μM, phentolamine was about as effective as an antagonist as yohimbine, whereas dihydroergotamine, WB-4101 and phenoxybenzamine were less effective and prazosin produced very… 

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