α2-Adrenoceptors modulating insulin release from isolated pancreatic islets

@article{Nakaki20042AdrenoceptorsMI,
  title={α2-Adrenoceptors modulating insulin release from isolated pancreatic islets},
  author={T. Nakaki and T. Nakadate and R. Kato},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={2004},
  volume={313},
  pages={151-153}
}
  • T. Nakaki, T. Nakadate, R. Kato
  • Published 2004
  • Medicine, Chemistry
  • Naunyn-Schmiedeberg's Archives of Pharmacology
  • SummaryUsing rat isolated pancreatic islets, we investigated the effects of various α-adrenoceptor blocking agents on adrenaline-induced inhibition of glucose-stimulated insulin release. Yohimbine was about 100 times more potent than prazosin in antagonizing the inhibitory effect of adrenaline. At concentrations of 10 μM, phentolamine was about as effective as an antagonist as yohimbine, whereas dihydroergotamine, WB-4101 and phenoxybenzamine were less effective and prazosin produced very… CONTINUE READING
    100 Citations

    Figures, Tables, and Topics from this paper.

    Yohimbine Increases Plasma Insulin Concentrations of Dogs
    • W. Hsu, D. D. Schaffer, M. Pineda
    • Chemistry, Medicine
    • Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
    • 1987
    • 15
    Dual action of clonidine on insulin release: suppression, but stimulation when α2-adrenoceptors are blocked
    • 19
    Effects of isoprenaline and glucagon on insulin secretion from pancreatic islets
    • 12

    References

    SHOWING 1-10 OF 17 REFERENCES
    Adrenergic regulation of blood glucose levels: possible involvement of postsynaptic alpha-2 type adrenergic receptors regulating insulin release.
    • 96
    Neuropharmacology of the pancreatic islets.
    • 112
    Alpha sympathomimetic inhibition of adrenergic and cholinergic transmission in the rabbit heart
    • K. Starke
    • Chemistry, Medicine
    • Naunyn-Schmiedeberg's Archives of Pharmacology
    • 2004
    • 238
    Blockade by WB 4101 of alpha-adrenoceptors in the rat vas deferens and guinea-pig taenia caeci.
    • 16
    The effects of alpha adrenergic agents on human platelet aggregation.
    • 112
    SELECTIVITY OF BLOCKING AGENTS FOR PRE‐ AND POSTSYNAPTIC α‐ADRENOCEPTORS
    • 396