α2-Adrenoceptors in the treatment of major neuropsychiatric disorders.

@article{Langer20152AdrenoceptorsIT,
  title={α2-Adrenoceptors in the treatment of major neuropsychiatric disorders.},
  author={Salomon Z. Langer},
  journal={Trends in pharmacological sciences},
  year={2015},
  volume={36 4},
  pages={
          196-202
        }
}
Presynaptic autoreceptors mediate a retrograde transfer of information by a negative feedback mechanism mediated by the transmitter of the neuron, and fulfill an autoregulatory function in neurotransmission in the peripheral and central nervous system (CNS). Starting with norepinephrine (NE), it was later reported that an autoreceptor-mediated negative feedback mechanism exists for other neurotransmitters, including dopamine (DA), serotonin, acetylcholine, histamine, GABA, and glutamate. This… CONTINUE READING
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