α2-Adrenoceptor agonist dexmedetomidine protects septic acute kidney injury through increasing BMP-7 and inhibiting HDAC2 and HDAC5.

@article{Hsing20122AdrenoceptorAD,
  title={α2-Adrenoceptor agonist dexmedetomidine protects septic acute kidney injury through increasing BMP-7 and inhibiting HDAC2 and HDAC5.},
  author={Chung-Hsi Hsing and Chiou-Feng Lin and Edmund Cheung So and Ding-Ping Sun and Tai-Chi Chen and C. Li and Ching-Hua Yeh},
  journal={American journal of physiology. Renal physiology},
  year={2012},
  volume={303 10},
  pages={F1443-53}
}
Bone morphogenetic protein (BMP)-7 protects sepsis-induced acute kidney injury (AKI). Dexmedetomidine (DEX), an α(2)-adrenoceptor (α(2)-AR) agonist, has anti-inflammatory effects. We investigated the protective effects of DEX on sepsis-induced AKI and the expression of BMP-7 and histone deacetylases (HDACs). In vitro, the effects of DEX or trichostatin A (TSA, an HDAC inhibitor) on TNF-α, monocyte chemotactic protein (MCP-1), BMP-7, and HDAC mRNA expression in LPS-stimulated rat renal tubular… CONTINUE READING
13 Citations
54 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 13 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 54 references

Histone deacetylase: a potential therapeutic target for fibrotic disorders

  • M Pang, S. Zhuang
  • J Pharmacol Exp Ther 335:
  • 2010
1 Excerpt

Similar Papers

Loading similar papers…