α2(I) collagen gene regulation by protein kinase C signaling in human dermal fibroblasts

@article{Jinnin20052ICG,
  title={α2(I) collagen gene regulation by protein kinase C signaling in human dermal fibroblasts},
  author={Masatoshi Jinnin and Hironobu Ihn and Kenichi Yamane and Yoshihiro Mimura and Yoshihide Asano and Kimitoshi Tamaki},
  journal={Nucleic Acids Research},
  year={2005},
  volume={33},
  pages={1337 - 1351}
}
We investigated the mechanisms by which protein kinase C (PKC) regulates the expression of the alpha2(I) collagen gene in normal dermal fibroblasts. Reduction of PKC-alpha activity by treatment with Gö697-6 or by overexpression of a dominant negative (DN) mutant form decreased alpha2(I) collagen gene expression. This decrease required a sequence element in the collagen promoter that contains Sp1/Sp3 binding sites. Reduction of PKC-delta activity by rottlerin or overexpression of DN PKC-delta… CONTINUE READING

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