α2,3-sialyltransferase type I regulates migration and peritoneal dissemination of ovarian cancer cells

@inproceedings{Wen201723sialyltransferaseTI,
  title={α2,3-sialyltransferase type I regulates migration and peritoneal dissemination of ovarian cancer cells},
  author={Kuo-Chang Wen and P L Sung and Shie-Liang Hsieh and Y T Chou and Oscar Kuang-Sheng Lee and Cheng-Wen Wu and Peng-Hui Wang},
  booktitle={Oncotarget},
  year={2017}
}
Epithelial ovarian cancer (EOC) has the highest mortality rate among gynecologic cancers due to advanced stage presentation, peritoneal dissemination, and refractory ascites at diagnosis. We investigated the role of α2,3-sialyltransferase type I (ST3GalI) by analyzing human ovarian cancer datasets and human EOC tissue arrays. We found that high expression of ST3GalI was associated with advanced stage EOC. Transwell migration and cell invasion assays showed that high ST3GalI expression enhanced… CONTINUE READING

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