α1‐ and α2‐Adrenoreceptor Antagonist Profiles of 1‐ and 2‐[ω‐(4‐Arylpiperazin‐1‐yl)alkyl]‐1,2,3‐benzotriazoles

@article{Boido20051A,
  title={$\alpha$1‐ and $\alpha$2‐Adrenoreceptor Antagonist Profiles of 1‐ and 2‐[$\omega$‐(4‐Arylpiperazin‐1‐yl)alkyl]‐1,2,3‐benzotriazoles},
  author={Alessandro Boido and Roberta Budriesi and Caterina Canu Boido and Pierfranco Ioan and Emanuela Terranova and Alberto Chiarini and Fabio Sparatore},
  journal={Chemistry \& Biodiversity},
  year={2005},
  volume={2}
}
A series of pharmacologically interesting 1‐ and 2‐[ω‐(4‐arylpiperazin‐1‐yl)alkyl]‐1,2,3‐benzotriazoles, compounds 1–27, were synthesized (Scheme) and subjected to various biological studies to identify structure–activity relationships (SAR). The new compounds were found to exhibit good non‐selective binding affinity towards the α1‐adrenoreceptor (Table 1). In several cases, high functional antagonism was observed towards the α1A‐, α1B‐, and α1D‐adrenoreceptor subtypes (Table 2). The… 
1 Citations
Thermal spin-crossover in the [M(3)Zn(6)Cl(6)L(12)] (M = Zn, Fe(II); L = 5,6-dimethoxy-1,2,3-benzotriazolate) system: structural, electrochemical, Mössbauer, and UV-Vis spectroscopic studies.
TLDR
Fusion of pentanuclear Kuratowski-type coordination units leads to homo- and heterononanuclear coordination compounds, two of which are presented, having structural formulae that exhibits a single reversible oxidation regardless of different Fe(II) spin states in the nonanuclear core of 2.

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