α-synuclein-lanthanide metal ions interaction: binding sites, conformation and fibrillation

Abstract

BACKGROUND The pathological hallmark of Parkinson's disease is the deposition of cytoplasmic neuronal inclusions termed Lewy bodies. The major component of Lewy bodies is amyloid fibrils of α-synuclein. To investigate what causes α-synuclein aggregation is essential to understand its pathological roles in Parkinson's disease. Various metal ions, including… (More)
DOI: 10.1186/s13628-016-0026-1

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