α-synuclein, LRRK2 and their interplay in Parkinson's disease.

@article{Liu2012synucleinLA,
  title={α-synuclein, LRRK2 and their interplay in Parkinson's disease.},
  author={Guoxiang Liu and Leonardo Aliaga and Huaibin Cai},
  journal={Future neurology},
  year={2012},
  volume={7 2},
  pages={145-153}
}
Of the various genetic factors contributing to the pathogenesis of Parkinson's disease (PD), only mutations in α-synuclein (α-syn) and LRRK2 genes cause clinical and neuropathological phenotypes closely resembling the sporadic cases. Therefore, studying the pathophysiological functions of these two PD-related genes is particularly informative in understanding the underlying molecular pathogenic mechanism of the disease. PD-related missense and multiplication mutations in α-syn may cause both… CONTINUE READING

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