α spectrin is essential for morphogenesis and body wall muscle formation in Caenorhabditis elegans

@article{Norman2002SI,
  title={α spectrin is essential for morphogenesis and body wall muscle formation in Caenorhabditis elegans},
  author={Kenneth R Norman and Donald G. Moerman},
  journal={The Journal of Cell Biology},
  year={2002},
  volume={157},
  pages={665 - 677}
}
A common feature of multicellular animals is the ubiquitous presence of the spectrin cytoskeleton. Although discovered over 30 yr ago, the function of spectrin in non-erythrocytes has remained elusive. We have found that the spc-1 gene encodes the only alpha spectrin gene in the Caenorhabditis elegans genome. During embryogenesis, alpha spectrin localizes to the cell membrane in most if not all cells, starting at the first cell stage. Interestingly, this localization is dependent on beta… CONTINUE READING
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