α-lipoic acid protects against hypoxia/reoxygenation-induced injury in human umbilical vein endothelial cells through suppression of apoptosis and autophagy

@inproceedings{Zhang2015lipoicAP,
  title={α-lipoic acid protects against hypoxia/reoxygenation-induced injury in human umbilical vein endothelial cells through suppression of apoptosis and autophagy},
  author={Jingjing Zhang and Houliang Deng and Li Liu and Xiaoxia Liu and Xialin Zuo and Qian Xu and Zhuomin Wu and Xiaobin Peng and Aimin Ji},
  booktitle={Molecular medicine reports},
  year={2015}
}
α-Lipoic acid (ALA) is known as a powerful antioxidant, which has been reported to have protective effects against various cardiovascular diseases. The present study aimed to determine whether ALA pre- or post-treatment induced protective effects against hypoxia/reoxygenation-induced injury via inhibition of apoptosis and autophagy in human umbilical vein endothelial cells (HUVECs). In order to simulate the conditions of hypoxia/reoxygenation, HUVECs were subjected to 4 h of oxygen-glucose… CONTINUE READING

References

Publications referenced by this paper.
SHOWING 1-10 OF 32 REFERENCES

alpha - lipoic acid protects dopaminergic neurons against MPP + - induced apoptosis by attenuating reactive oxygen species formation

TJ Cheng, YJ Wang, WW Kao, RJ Chen, YS Ho
  • Int J Mol Med
  • 2013

The impact of lipoic acid on endothelial function and proteinuria in quinapril - treated diabetic patients with stage i hypertension results from the quality study

EH Bae, KS Lee, +9 authors SW Kim
  • J Cardiovasc Pharmacol Ther
  • 2012

The protective effect of alpha lipoic acid on Schwann cells exposed to constant or intermittent high glucose

J Roquer, T Segura, J Serena, J Castillo
  • Biochem Pharmacol
  • 2012