α-Tubulin mutations alter oryzalin affinity and microtubule assembly properties to confer dinitroaniline resistance.

@article{LyonsAbbott2010TubulinMA,
  title={α-Tubulin mutations alter oryzalin affinity and microtubule assembly properties to confer dinitroaniline resistance.},
  author={Sally Lyons-Abbott and Dan L. Sackett and Dorota Wloga and Jacek Gaertig and Rachel E. Morgan and Karl A. Werbovetz and Naomi S. Morrissette},
  journal={Eukaryotic cell},
  year={2010},
  volume={9 12},
  pages={1825-34}
}
Plant and protozoan microtubules are selectively sensitive to dinitroanilines, which do not disrupt vertebrate or fungal microtubules. Tetrahymena thermophila is an abundant source of dinitroaniline-sensitive tubulin, and we have modified the single T. thermophila α-tubulin gene to create strains that solely express mutant α-tubulin in functional dimers. Previous research identified multiple α-tubulin mutations that confer dinitroaniline resistance in the human parasite Toxoplasma gondii, and… CONTINUE READING

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Dinitroaniline interactions with tubulin: genetic and computational approaches to define the mechanisms of action and resistance, p. 327–350

  • N. S. Morrissette, D. Sept
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