α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging.

Abstract

We report that α-tocotrienol quinone (ATQ3) is a metabolite of α-tocotrienol, and that ATQ3 is a potent cellular protectant against oxidative stress and aging. ATQ3 is orally bioavailable, crosses the blood-brain barrier, and has demonstrated clinical response in inherited mitochondrial disease in open label studies. ATQ3 activity is dependent upon reversible 2e-redox-cycling. ATQ3 may represent a broader class of unappreciated dietary-derived phytomolecular redox motifs that digitally encode biochemical data using redox state as a means to sense and transfer information essential for cellular function.

DOI: 10.1016/j.bmcl.2011.04.085

Cite this paper

@article{Shrader2011TocotrienolQM, title={α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging.}, author={William D Shrader and Akiko Amagata and Adam Barnes and Gregory M. Enns and Andrew Hinman and Orion D Jankowski and Viktoria Kheifets and Ryo Komatsuzaki and Edgar L Lee and Paul Mollard and Katsuyuki Murase and Alfredo Arrigo Sadun and Martin J. M. C. Thoolen and Kieron E Wesson and Guy S. Miller}, journal={Bioorganic & medicinal chemistry letters}, year={2011}, volume={21 12}, pages={3693-8} }