α-Tocopherol transfer protein is not required for the discrimination against γ-tocopherol in vivo but protects it from side-chain degradation in vitro.

@article{Grebenstein2014TocopherolTP,
  title={α-Tocopherol transfer protein is not required for the discrimination against γ-tocopherol in vivo but protects it from side-chain degradation in vitro.},
  author={Nadine Grebenstein and Monika Schumacher and Lutz Graeve and Jan Frank},
  journal={Molecular nutrition & food research},
  year={2014},
  volume={58 5},
  pages={1052-60}
}
SCOPE The mechanisms underlying the preferential retention of a single compound (α-tocopherol (αT)) of the eight vitamin E compounds in the body are incompletely understood. We hypothesized that vitamin E metabolism and not the hepatic α-tocopherol transfer protein (TTP) is responsible for the discrimination against non-αT congeners. METHODS AND RESULTS TTP knockout and wild-type mice (n = 12/group) were fed equimolar concentrations of αT and γ-tocopherol (γT; 50 mg/kg diet each) alone or… CONTINUE READING

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