α-Thujone reduces 5-HT3 receptor activity by an effect on the agonist-induced desensitization

@article{Deiml2004ThujoneR5,
  title={$\alpha$-Thujone reduces 5-HT3 receptor activity by an effect on the agonist-induced desensitization},
  author={Tobias Deiml and Rainer Haseneder and Walter Zieglg{\"a}nsberger and Gerhard Rammes and Brigitte Eisensamer and Rainer Rupprecht and Gerhard Hapfelmeier},
  journal={Neuropharmacology},
  year={2004},
  volume={46},
  pages={192-201}
}
Abstract The convulsant effects of α-thujone, the psychotropic component of absinthe, were attributed to inhibitory actions at the GABAA receptor. Here, we investigated for the first time the 5-HT3 receptor as a potential site of the psychotropic actions of α-thujone. This cation permeable ligand-gated ion channel shows considerable homology to the GABAA receptor. We previously demonstrated that in homomeric assemblies of cloned human 5-HT3A receptor subunits, the endogenous agonist 5-HT… Expand
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