α-Synuclein structure, posttranslational modification and alternative splicing as aggregation enhancers

@article{Beyer2006SynucleinSP,
  title={α-Synuclein structure, posttranslational modification and alternative splicing as aggregation enhancers},
  author={Katrin Beyer},
  journal={Acta Neuropathologica},
  year={2006},
  volume={112},
  pages={237-251}
}
Abstractα-Synuclein aggregation is thought to be a key event in the pathogenesis of synucleinopathies. Although different α-synuclein alterations and modifications have been proposed to be responsible for early aggregation steps, the mechanisms underlying these events remain unclarified. α-Synuclein is a small protein localized to synaptic terminals and its intrinsic structure has been claimed to be an important factor for self-oligomerization and self-aggregation. α-Synuclein expression… CONTINUE READING
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