α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation

Abstract

Parkinson's disease is the second most common neurodegenerative disorder. Growing evidence indicates a causative role of misfolded forms of the protein α-synuclein in the pathogenesis of Parkinson's disease. Intraneuronal aggregates of α-synuclein occur in Lewy bodies and Lewy neurites, the cytopathological hallmarks of Parkinson's disease and related… (More)
DOI: 10.1038/nature10324

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Cite this paper

@inproceedings{Bartels2011SynucleinOP, title={α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation}, author={Tim Bartels and Joanna G. Choi and Dennis J. Selkoe}, booktitle={Nature}, year={2011} }