α-Synuclein membrane association is regulated by the Rab3a recycling machinery and presynaptic activity.

@article{Chen2013SynucleinMA,
  title={α-Synuclein membrane association is regulated by the Rab3a recycling machinery and presynaptic activity.},
  author={Robert Chien-Chung Chen and Sabine Wislet-Gendebien and Filsy G Samuel and Naomi P. Visanji and Gang Zhang and Diana Marsilio and Tammy Langman and Paul E. Fraser and Anurag Tandon},
  journal={The Journal of biological chemistry},
  year={2013},
  volume={288 11},
  pages={7438-49}
}
α-Synuclein is an abundant presynaptic protein and a primary component of Lewy bodies in Parkinson disease. Although its pathogenic role remains unclear, in healthy nerve terminals α-synuclein undergoes a cycle of membrane binding and dissociation. An α-synuclein binding assay was used to screen for vesicle proteins involved in α-synuclein membrane interactions and showed that antibodies directed to the Ras-related GTPase Rab3a and its chaperone RabGDI abrogated α-synuclein membrane binding… CONTINUE READING
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