α-Synuclein levels affect autophagosome numbers in vivo and modulate Huntington disease pathology.

@article{Corrochano2012SynucleinLA,
  title={α-Synuclein levels affect autophagosome numbers in vivo and modulate Huntington disease pathology.},
  author={Silvia Corrochano and Maurizio Renna and Cristina Tom{\'a}s-Zapico and Steve D. M. Brown and Jos{\'e} J Lucas and David C Rubinsztein and Abraham Acevedo-Arozena},
  journal={Autophagy},
  year={2012},
  volume={8 3},
  pages={431-2}
}
Huntington and Parkinson diseases (HD and PD) are two major neurodegenerative disorders pathologically characterized by the accumulation of the aggregate-prone proteins mutant huntingtin (in HD) and α-synuclein (in PD). Mutant huntingtin is an autophagy substrate and autophagy modulators affect HD pathology both in vitro and in vivo. In vitro, α-synuclein… CONTINUE READING