α-Synuclein expression in the substantia nigra of MPTP-lesioned non-human primates

@article{Purisai2005SynucleinEI,
  title={α-Synuclein expression in the substantia nigra of MPTP-lesioned non-human primates},
  author={Maya G. Purisai and Alison L. McCormack and William J. Langston and Louisa Clare Johnston and Donato A. Di Monte},
  journal={Neurobiology of Disease},
  year={2005},
  volume={20},
  pages={898-906}
}
Changes in the expression of A-synuclein are likely to underlie its normal function as well as its role in pathological processes. The relationship between toxic injury and A-synuclein expression was assessed in the substantia nigra of squirrel monkeys treated with a single injection of MPTP and sacrificed 1 week or 1 month later. At 1 week, when stereological cell counting revealed only a small decrease ( 10%) in the number of dopaminergic neurons, A-synuclein mRNA and protein were markedly… CONTINUE READING

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