α-Synuclein binds the K(ATP) channel at insulin-secretory granules and inhibits insulin secretion.

@article{Geng2011SynucleinBT,
  title={α-Synuclein binds the K(ATP) channel at insulin-secretory granules and inhibits insulin secretion.},
  author={Xuehui Geng and Haiyan Lou and Jian Wang and Lehong Li and Alexandra Swanson and Ming Sun and Donna Beers-Stolz and S. Watkins and Ruth G. Perez and Peter Drain},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2011},
  volume={300 2},
  pages={E276-86}
}
α-Synuclein has been studied in numerous cell types often associated with secretory processes. In pancreatic β-cells, α-synuclein might therefore play a similar role by interacting with organelles involved in insulin secretion. We tested for α-synuclein localizing to insulin-secretory granules and characterized its role in glucose-stimulated insulin secretion. Immunohistochemistry and fluorescent sulfonylureas were used to test for α-synuclein localization to insulin granules in β-cells… CONTINUE READING

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