α-Synuclein Transgenic Mice Reveal Compensatory Increases in Parkinson's Disease-Associated Proteins DJ-1 and Parkin and Have Enhanced α-Synuclein and PINK1 Levels After Rotenone Treatment

@article{George2010SynucleinTM,
  title={α-Synuclein Transgenic Mice Reveal Compensatory Increases in Parkinson's Disease-Associated Proteins DJ-1 and Parkin and Have Enhanced α-Synuclein and PINK1 Levels After Rotenone Treatment},
  author={Sonia George and Su San Mok and Milawaty Nurjono and Scott Ayton and David Isaac Finkelstein and Colin L. Masters and Qiao-xin Li and Janetta Gladys Culvenor},
  journal={Journal of Molecular Neuroscience},
  year={2010},
  volume={42},
  pages={243-254}
}
Parkinson's disease (PD) is a severe neurodegenerative disorder characterised by loss of dopaminergic neurons of the substantia nigra. The pathological hallmarks are cytoplasmic inclusions termed Lewy bodies consisting primarily of aggregated α-synuclein (αSN). Different lines of transgenic mice have been developed to model PD but have failed to recapitulate the hallmarks of this disease. Since treatment of rodents with the pesticide rotenone can reproduce nigrostriatal cell loss and other… CONTINUE READING

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