α-Synuclein Senses Lipid Packing Defects and Induces Lateral Expansion of Lipids Leading to Membrane Remodeling*

@article{Ouberai2013SynucleinSL,
  title={α-Synuclein Senses Lipid Packing Defects and Induces Lateral Expansion of Lipids Leading to Membrane Remodeling*},
  author={Myriam M. Ouberai and J. Wang and M. Swann and C{\'e}line Galvagnion and Tim Guilliams and C. Dobson and M. Welland},
  journal={The Journal of Biological Chemistry},
  year={2013},
  volume={288},
  pages={20883 - 20895}
}
  • Myriam M. Ouberai, J. Wang, +4 authors M. Welland
  • Published 2013
  • Chemistry, Medicine
  • The Journal of Biological Chemistry
  • Background: α-Synuclein folds into an amphipathic α-helical structure upon membrane interaction. Results: The binding is promoted by lipid packing defects found in vesicles of high curvature and in planar membranes with cone-shaped lipids. Conclusion: The insertion of α-synuclein induces a lateral expansion of lipids that can progress to membrane remodeling. Significance: These findings support the role of α-synuclein in vesicle trafficking. There is increasing evidence for the involvement of… CONTINUE READING
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