α-Synuclein Membrane Association Is Regulated by the Rab3a Recycling Machinery and Presynaptic Activity*♦

@article{Chen2013SynucleinMA,
  title={α-Synuclein Membrane Association Is Regulated by the Rab3a Recycling Machinery and Presynaptic Activity*♦},
  author={R. C. Chen and S. Wislet-Gendebien and Filsy Samuel and N. Visanji and G. Zhang and Diana Marsilio and Tammy Langman and P. Fraser and A. Tandon},
  journal={The Journal of Biological Chemistry},
  year={2013},
  volume={288},
  pages={7438 - 7449}
}
Background: α-Synuclein is known to undergo exchange between membrane and cytosolic compartments. Results: α-Synuclein interacts with GTP-bound Rab3a on synaptic vesicles, and its dissociation is mediated by GDI/Hsp90. Conclusion: α-Synuclein's membrane association and dissociation cycle is linked to synaptic activity by the Rab3a recycling machinery. Significance: Significance: Impairments to α-synuclein interactions with vesicles and with the Rab3a recycling machinery may affect… Expand
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References

SHOWING 1-10 OF 80 REFERENCES
Cytosolic Proteins Regulate α-Synuclein Dissociation from Presynaptic Membranes*
  • 54
  • PDF
α-Synuclein Inhibits Intersynaptic Vesicle Mobility and Maintains Recycling-Pool Homeostasis
  • 165
  • PDF
The Parkinson's disease protein α-synuclein disrupts cellular Rab homeostasis
  • 401
  • PDF
Differential regulation of wild-type and mutant alpha-synuclein binding to synaptic membranes by cytosolic factors
  • 28
  • PDF
The Association of α-Synuclein with Membranes Affects Bilayer Structure, Stability, and Fibril Formation*
  • 286
  • PDF
α-Synuclein Membrane Interactions and Lipid Specificity*
  • 468
  • PDF
A Combinatorial Code for the Interaction of α-Synuclein with Membranes*
  • 153
  • PDF
Membrane binding and self-association of alpha-synucleins.
  • 152
...
1
2
3
4
5
...