α-Syntrophin regulates ARMS localization at the neuromuscular junction and enhances EphA4 signaling in an ARMS-dependent manner

@article{Luo2005SyntrophinRA,
  title={α-Syntrophin regulates ARMS localization at the neuromuscular junction and enhances EphA4 signaling in an ARMS-dependent manner},
  author={Shuo Luo and Yu Chen and Kwok-On Lai and Juan C Ar{\'e}valo and Stanley C. Froehner and Marvin E. Adams and Moses V Chao and Nancy Y Ip},
  journal={The Journal of Cell Biology},
  year={2005},
  volume={169},
  pages={813 - 824}
}
EphA4 signaling has recently been implicated in the regulation of synapse formation and plasticity. In this study, we show that ankyrin repeat-rich membrane spanning (ARMS; also known as a kinase D-interacting substrate of 220 kD), a substrate for ephrin and neurotrophin receptors, was expressed in developing muscle and was concentrated at the neuromuscular junction (NMJ). Using yeast two-hybrid screening, we identified a PDZ (PSD-95, Dlg, ZO-1) domain protein, alpha-syntrophin, as an ARMS… CONTINUE READING
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