α-Scorpion Toxin Impairs a Conformational Change that Leads to Fast Inactivation of Muscle Sodium Channels

@article{Campos2008ScorpionTI,
  title={α-Scorpion Toxin Impairs a Conformational Change that Leads to Fast Inactivation of Muscle Sodium Channels},
  author={Fabiana Vasconcelos Campos and Baron Chanda and Paulo S. L. Beir{\~a}o and Francisco Bezanilla},
  journal={The Journal of General Physiology},
  year={2008},
  volume={132},
  pages={251 - 263}
}
Alpha-scorpion toxins bind in a voltage-dependent way to site 3 of the sodium channels, which is partially formed by the loop connecting S3 and S4 segments of domain IV, slowing down fast inactivation. We have used Ts3, an alpha-scorpion toxin from the Brazilian scorpion Tityus serrulatus, to analyze the effects of this family of toxins on the muscle sodium channels expressed in Xenopus oocytes. In the presence of Ts3 the total gating charge was reduced by 30% compared with control conditions… CONTINUE READING

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