α-Mannosidase 2C1 attenuates PTEN function in prostate cancer cells.

@article{He2011Mannosidase2A,
  title={α-Mannosidase 2C1 attenuates PTEN function in prostate cancer cells.},
  author={Lizhi He and Catherine Fan and Anil B. Kapoor and Alistair J. Ingram and Adrian P. Rybak and Richard C Austin and Jeffery Dickhout and J C Cutz and James William Scholey and Damu Tang},
  journal={Nature communications},
  year={2011},
  volume={2},
  pages={307}
}
PTEN dephosphorylates the 3-position phosphate of phosphatidylinositol 3,4,5 triphosphate (PIP(3)), thereby inhibiting AKT activation. Although attenuation of PTEN function has a major role in tumourigenesis, the underlying mechanisms remain unclear. Here we show that α-mannosidase 2C1 (MAN2C1) inhibits PTEN function in prostate cancer (PC) cells and is associated with a reduction in PTEN function in primary PC. MAN2C1 activates AKT and promotes the formation of PTEN-positive DU145 cell-derived… CONTINUE READING
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