α-MSH-stimulated tolerogenic dendritic cells induce functional regulatory T cells and ameliorate ongoing skin inflammation.

@article{Auriemma2012MSHstimulatedTD,
  title={α-MSH-stimulated tolerogenic dendritic cells induce functional regulatory T cells and ameliorate ongoing skin inflammation.},
  author={Matteo Auriemma and Thomas Brzoska and Laura Gallardo Klenner and Verena Kupas and Tobias Goerge and Maik Voskort and Zuotao Zhao and Tim Sparwasser and Thomas Anton Luger and Karin Loser},
  journal={The Journal of investigative dermatology},
  year={2012},
  volume={132 7},
  pages={1814-24}
}
The neuropeptide α-melanocyte-stimulating hormone (α-MSH) is a well-known mediator of skin pigmentation. More recently, it has been shown that α-MSH also exerts a strong anti-inflammatory and immunosuppressive activity. To elucidate the mechanisms underlying α-MSH-induced immunosuppression, we investigated whether α-MSH affects dendritic cell/T cell communication, as especially this interaction has an important role in the regulation of immune responses. Here, we show that α-MSH, by binding to… CONTINUE READING

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