α-MSH potentiates the responsiveness of mammotropes by increasing Ca2+ entry.

@article{Nez1998MSHPT,
  title={α-MSH potentiates the responsiveness of mammotropes by increasing Ca2+ entry.},
  author={Luc{\'i}a N{\'u}{\~n}ez and L. Stephen Frawley},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={1998},
  volume={274 6},
  pages={E971-E977}
}
It is well known that the suckling stimulus renders mammotropes considerably more responsive to prolactin (PRL)-releasing stimuli, and the neurointermediate lobe peptide α-melanocyte-stimulating hormone (α-MSH) has been proposed to play a pivotal role in this priming. The objectives of the present study were to determine whether α-MSH could act directly on pituitary cells to potentiate PRL release in response to two physiologically relevant PRL secretagogues, thyrotropin-releasing hormone (TRH… CONTINUE READING