α-Lipoic acid treatment prevents cystine urolithiasis in a mouse model of cystinuria

Abstract

Cystinuria is an incompletely dominant disorder characterized by defective urinary cystine reabsorption that results in the formation of cystine-based urinary stones. Current treatment options are limited in their effectiveness at preventing stone recurrence and are often poorly tolerated. We report that the nutritional supplement α-lipoic acid inhibits cystine stone formation in the Slc3a1−/− mouse model of cystinuria by increasing the solubility of urinary cystine. These findings identify a novel therapeutic strategy for the clinical treatment of cystinuria.

DOI: 10.1038/nm.4280

2 Figures and Tables

Cite this paper

@inproceedings{Zee2017LipoicAT, title={α-Lipoic acid treatment prevents cystine urolithiasis in a mouse model of cystinuria}, author={Tiffany Zee and Neelanjan Bose and Jarcy Zee and Jennifer N. Beck and See Yang and Jaspreet Singh Parihar and Min Yang and Sruthi Damodar and David J. Hall and Monique N. O'Leary and Arvind Ramanathan and Roy R.L Gerona and David W Killilea and Thomas Chi and Jay A. Tischfield and Amrik Sahota and Arnold J. Kahn and Marshall L. Stoller and Pankaj Kapahi}, booktitle={Nature Medicine}, year={2017} }