α-Lipoic acid normalizes nociceptive neuronal activity at the spinal cord of diabetic rats.

@article{Morgado2011LipoicAN,
  title={α-Lipoic acid normalizes nociceptive neuronal activity at the spinal cord of diabetic rats.},
  author={Carla Morgado and Patr{\'i}cia Pereira-Terra and Isaura Tavares},
  journal={Diabetes, obesity & metabolism},
  year={2011},
  volume={13 8},
  pages={736-41}
}
AIM To evaluate the effects of antioxidant treatment of streptozotocin (STZ)-diabetic rats with α-lipoic acid (α-LA) in neuronal and microglial activation at the spinal cord, an important relay station of nociceptive transmission. Because of the role of the potassium chloride co-transporter 2 (KCC2) in neuronal activation at the spinal cord and the influence of microglia in KCC2 expression, we also evaluated the effects of α-LA in KCC2 expression at the spinal cord. METHODS Four weeks after… CONTINUE READING

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