• Corpus ID: 19335584

α-Linolenic acid metabolism in men and women: nutritional and biological implications

@article{Burdge2004LinolenicAM,
  title={$\alpha$-Linolenic acid metabolism in men and women: nutritional and biological implications},
  author={Graham C. Burdge},
  journal={Current Opinion in Clinical Nutrition and Metabolic Care},
  year={2004},
  volume={7},
  pages={137-144}
}
  • G. Burdge
  • Published 1 March 2004
  • Medicine
  • Current Opinion in Clinical Nutrition and Metabolic Care
Purpose of reviewThis review critically evaluates current knowledge of α-linolenic acid metabolism in adult humans based on the findings of studies using stable isotope tracers and on increased dietary α-linolenic acid intake. The relative roles of α-linolenic acid and of longer-chain polyunsaturated fatty acids in cell structure and function are discussed together with an overview of the major metabolic fates of α-linolenic acid. The extent of partitioning towards β-oxidation and carbon… 

Figures and Tables from this paper

Dietary linoleic acid requirements in the presence of α-linolenic acid are lower than the historical 2 % of energy intake value, study in rats
TLDR
The first step shows that the best LA deficiency model was obtained using rats fed the 0LA/0ALA diet, and demonstrates that in growing rats, LA deficiency was corrected with an intake of 1–1·5 en% from LA and 0·5En% from ALA.
Long-chain conversion of [13C]linoleic acid and alpha-linolenic acid in response to marked changes in their dietary intake in men.
TLDR
Long-chain conversion of ALA and [U-13C]LA was similar but low for the two tracers and varied directly with precursor concentrations and inversely with concentrations of fatty acids of the alternative series.
Quantitation of alpha-linolenic acid elongation to eicosapentaenoic and docosahexaenoic acid as affected by the ratio of n6/n3 fatty acids
TLDR
Formation of EPA and DHA was highest at an administered LA/ALA ratio of 1:1, although gene expression of PPARα, SREBP-1c and D5D involved in ALA elongation were higher in the presence of ALA solely.
Long-chain n-3 PUFA in vegetarian women: a metabolic perspective
TLDR
EPA and DHA status was lower in breast milk and in infants of vegetarian mothers than those born to omnivore mothers, which suggests that in the absence of pre-formed dietary EPA and D HA, synthesis from α-linolenic acid is an important process in determining maternal EPA andDHA status in pregnancy.
Les rôles physiologiques majeurs exercés par les acides gras polyinsaturés (AGPI)
TLDR
The dietary intake of omega 3 fatty acid (α-linolenate and also docosahexaenoate) are crucial parameters in the development of retinal and neural function in the newborn infant and a high ratio of omega6/omega 3 fatty acids in cell membranes may promote the pathogenesis of several diseases, including cardiovascular diseases, metabolic syndrome, inflammatory disorders and obesity.
Prescription omega-3 fatty acids for the treatment of hypertriglyceridemia.
  • J. Mckenney, D. Sica
  • Medicine
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists
  • 2007
TLDR
P-O3FA has demonstrated an efficacy and safety in adult patients with high and very high triglycerides adjunct to diet, and the reduction in serum triglyceride levels was dependent on the baseline triglycerides levels.
Association between the intake of α-linolenic acid and the risk of CHD.
TLDR
The intake of the mainly plant-derived n-3 PUFA α-linolenic acid (ALA) has been reported to be associated with a lower risk of CHD, and an inverse association between the intake of ALA and the risk ofCHD events and deaths was observed among men.
ω-3 Long-Chain Polyunsaturated Fatty Acids and Fatty Acid Desaturase Activity Ratios as Eventual Endophenotypes for ADHD
TLDR
DHA/ALA, DHA/DPA, serum DPA, and serum ALA may be suitable as endophenotypes for ADHD women, as compared with ADHD females and unaffected relatives of index cases.
Atherosclerosis, Dyslipidemia, and Inflammation: The Significant Role of Polyunsaturated Fatty Acids
TLDR
Several studies suggested the relationship between long-chain n-3 polyunsaturated fatty acids and inflammation, showing that fatty acids may decrease endothelial activation and affect eicosanoid metabolism.
...
...

References

SHOWING 1-10 OF 81 REFERENCES
Isomerization increases the postprandial oxidation of linoleic acid but not alpha-linolenic acid in men.
TLDR
It is shown that isomerization increases the postprandial oxidation of linoleic acid but not alpha-linolenic acid in men, and their major trans isomers in human volunteers.
Dietary α-linolenic acid alters tissue fatty acid composition, but not blood lipids, lipoproteins or coagulation status in humans
TLDR
Dietary ALA, fed for 56 d at 6.3% of calories, had no effect on plasma triglyceride or very low density lipoprotein levels or the common risk factors associated with atherosclerosis, although these parameters have been reported by others to be influenced by fatty acids, such as palmitic or linoleic acids, in the diet.
Differential oxidation of individual dietary fatty acids in humans.
TLDR
Lauric acid is highly oxidized, whereas the polyunsaturated and monounsaturated fatty acids are fairly well oxidized; Oxidation of the long-chain, saturated fatty acids decreases with increasing carbon number.
Effect of dietary α-linolenic acid and its ratio to linoleic acid on platelet and plasma fatty acids and thrombogenesis
TLDR
Both the level of 18∶3n−3 in the diet and its ratio to 18∵2n−6 were important in influencing long-chain n−3 fatty acid levels in platelet and plasma PL and that prostanoid production coincided with the diet-induced differences in PL fatty acid patterns.
Arachidonic and docosahexaenoic acids are biosynthesized from their 18-carbon precursors in human infants.
TLDR
The results demonstrate that human infants have the capacity to convert dietary essential fatty acids administered enterally as 2H-labeled ethyl esters to their longer-chain derivatives, transport them to plasma, and incorporate them into membrane lipids.
Effects of beef- and fish-based diets on the kinetics of n-3 fatty acid metabolism in human subjects.
TLDR
The primary effect of a fish-based diet on the kinetics of n-3 metabolism involves processes that inhibit the synthesis of 22:6n-3 from 22:5N-3, and these processes may involve a system of feedback control mechanisms responsive to the plasma concentration of 23:5n- 3.
Alpha-linolenic acid in rapeseed oil partly compensates for the effect of fish restriction on plasma long chain n-3 fatty acids.
TLDR
AlA is metabolized to EPA in humans to a significant extent and resembled the effect of a weekly portion of fatty fish depending on the fat content of the fish.
Contribution of dietary and newly formed arachidonic acid to human milk lipids in women eating a low-fat diet.
TLDR
The results suggest that maternal body stores are the major source of milk LA and AA in women eating a low-fat diet in these women.
...
...