α-Linolenic acid attenuates doxorubicin-induced cardiotoxicity in rats through suppression of oxidative stress and apoptosis.

@article{Yu2013LinolenicAA,
  title={α-Linolenic acid attenuates doxorubicin-induced cardiotoxicity in rats through suppression of oxidative stress and apoptosis.},
  author={Xiaohua Yu and Libao Cui and Zizhen Zhang and Qihui Zhao and Shuangjie Li},
  journal={Acta biochimica et biophysica Sinica},
  year={2013},
  volume={45 10},
  pages={817-26}
}
Doxorubicin (DOX), a widely used anti-tumor drug, can give rise to severe cardiotoxicity by oxidative stress and cell apoptosis, which restricts its clinical application. α-Linolenic acid (ALA) has been shown to serve as a potent cardioprotective agent. The aim of this study was to explore the protective effects of ALA on DOX-induced cardiotoxicity and the underlying molecular mechanisms for this cardioprotection in rats. Rats were randomly divided into four groups and administrated with normal… CONTINUE READING

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