α-Ketoacid dehydrogenase complexes and respiratory fuel utilisation in diabetes

Abstract

Activity of the pyruvate dehydrogenase complex determines the rate of glucose oxidation in animals including man. The complex is regulated by reversible phosphorylation, phosphorylation resulting in inactivation. Activity is therefore dependent upon the activities of pyruvate dehydrogenase kinase and phosphatase. Activity of the complex is reduced in… (More)
DOI: 10.1007/BF00281981

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Cite this paper

@article{Randle1985KetoacidDC, title={α-Ketoacid dehydrogenase complexes and respiratory fuel utilisation in diabetes}, author={Philip J. Randle}, journal={Diabetologia}, year={1985}, volume={28}, pages={479-484} }