α-Hispanolol Induces Apoptosis and Suppresses Migration and Invasion of Glioblastoma Cells Likely via Downregulation of MMP-2/9 Expression and p38MAPK Attenuation

@article{SnchezMartn2019HispanololIA,
  title={$\alpha$-Hispanolol Induces Apoptosis and Suppresses Migration and Invasion of Glioblastoma Cells Likely via Downregulation of MMP-2/9 Expression and p38MAPK Attenuation},
  author={V. S{\'a}nchez-Mart{\'i}n and Lidia Jim{\'e}nez-Garc{\'i}a and S. Herr{\'a}nz and A. Luque and P. Acebo and {\'A}ngel Amesty and A. Est{\'e}vez-Braun and B. de Las Heras and S. Hortelano},
  journal={Frontiers in Pharmacology},
  year={2019},
  volume={10}
}
α-Hispanolol (α-H) is a labdane diterpenoid that has been shown to induce apoptosis in several human cancer cells. However, the effect of α-H in human glioblastoma cells has not been described. In the present work, we have investigated the effects of α-H on apoptosis, migration, and invasion of human glioblastoma cells with the aim of identifying the molecular targets underlying its mechanism of action. The results revealed that α-H showed significant cytotoxicity against human glioma cancer… Expand

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