α-Actinin-3 deficiency is associated with reduced bone mass in human and mouse.

Abstract

Bone mineral density (BMD) is a complex trait that is the single best predictor of the risk of osteoporotic fractures. Candidate gene and genome-wide association studies have identified genetic variations in approximately 30 genetic loci associated with BMD variation in humans. α-Actinin-3 (ACTN3) is highly expressed in fast skeletal muscle fibres. There is… (More)
DOI: 10.1016/j.bone.2011.07.009

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Cite this paper

@article{Yang2011Actinin3DI, title={α-Actinin-3 deficiency is associated with reduced bone mass in human and mouse.}, author={Nan Yang and Aaron Schindeler and Michelle M McDonald and Jane T C Seto and Peter J. Houweling and Monkol Lek and Marshall Hogarth and Alyson Morse and Joanna M. Raftery and Dominic Balasuriya and Daniel G. MacArthur and Yemima D Berman and Kate G. R. Quinlan and John A. Eisman and Tuan V. Nguyen and Jacqueline R. Center and Richard L Prince and Scott G. Wilson and Kathy Zhu and David Graham Little and Kathryn N North}, journal={Bone}, year={2011}, volume={49 4}, pages={790-8} }