α-1-antitrypsin variants and the proteinase/antiproteinase imbalance in chronic obstructive pulmonary disease.

@article{Sinden20151antitrypsinVA,
  title={α-1-antitrypsin variants and the proteinase/antiproteinase imbalance in chronic obstructive pulmonary disease.},
  author={Nicola Jane Sinden and M. J. Baker and David J. Smith and Jan-Ulrich Kreft and Timothy R. Dafforn and Robert Andrew Stockley},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2015},
  volume={308 2},
  pages={L179-90}
}
The excessive activities of the serine proteinases neutrophil elastase and proteinase 3 are associated with tissue damage in chronic obstructive pulmonary disease. Reduced concentrations and/or inhibitory efficiency of the main circulating serine proteinase inhibitor α-1-antitrypsin result from point mutations in its gene. In addition, α-2-macroglobulin competes with α-1-antitrypsin for proteinases, and the α-2-macroglobulin-sequestered enzyme can retain its catalytic activity. We have studied… CONTINUE READING
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