α₂-Adrenoceptor functionality in postmortem frontal cortex of depressed suicide victims.

@article{Valdizn2010AdrenoceptorFI,
  title={α₂-Adrenoceptor functionality in postmortem frontal cortex of depressed suicide victims.},
  author={Elsa Mar{\'i}a Valdiz{\'a}n and Rebeca Diez-Alarcia and Javier Gonz{\'a}lez-Maeso and Fuencisla Pilar-Cu{\'e}llar and Jes{\'u}s Andr{\'e}s Garc{\'i}a-Sevilla and J Javier Meana and {\'A}ngel Pazos},
  journal={Biological psychiatry},
  year={2010},
  volume={68 9},
  pages={869-72}
}
BACKGROUND Alterations in brain density and signaling associated with monoamine receptors are believed to play a role in depressive disorders. This study evaluates the functional status of α₂(A)-adrenoceptors in postmortem frontal cortex of depressed subjects. METHODS G-protein activation and inhibition of adenylyl cyclase (AC) activity induced by the α₂-adrenoceptor agonist UK14304 were measured in triplicate in samples from 15 suicide victims with an antemortem diagnosis of major depression… CONTINUE READING
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Role of the serotonergic system in the pathogenesis of major depression and suicidal behavior. Neuropsychopharmacology

  • JJ Mann
  • 1999
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