α₁-Antitrypsin protease inhibitor MZ heterozygosity is associated with airflow obstruction in two large cohorts.

@article{Srheim2010AntitrypsinPI,
  title={α₁-Antitrypsin protease inhibitor MZ heterozygosity is associated with airflow obstruction in two large cohorts.},
  author={I C S\orheim and Per S. Bakke and Amund Gulsvik and Sreekumar G Pillai and Ane Johannessen and Per Ivar Gaarder and Edward J. Campbell and Alvar Agust{\'i} and Peter M. A. Calverley and Claudio Ferdinando Donner and Barry J. Make and Stephen I. Rennard and J\orgen Vestbo and Emiel F. M. Wouters and Peter D. Par{\'e} and Robert D. Levy and Harvey O Coxson and David A. Lomas and Craig P. Hersh and Edwin K. Silverman},
  journal={Chest},
  year={2010},
  volume={138 5},
  pages={1125-32}
}
BACKGROUND Severe α₁-antitrypsin deficiency is a known genetic risk factor for COPD. Heterozygous (protease inhibitor [PI] MZ) individuals have moderately reduced serum levels of α₁-antitrypsin, but whether they have an increased risk of COPD is uncertain. METHODS We compared PI MZ and PI MM individuals in two large populations: a case-control study from Norway (n = 1,669) and a multicenter family-based study from Europe and North America (n = 2,707). We sought to determine whether PI MZ was… CONTINUE READING

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