α₁-Antitrypsin modulates lung endothelial cell inflammatory responses to TNF-α.

@article{Lockett2013AntitrypsinML,
  title={α₁-Antitrypsin modulates lung endothelial cell inflammatory responses to TNF-α.},
  author={Angelia D. Lockett and Samuel T. Kimani and Godfrey Ddungu and Sabine Wrenger and Rubin M. Tuder and Sabina Janciauskiene and Irina Petrache},
  journal={American journal of respiratory cell and molecular biology},
  year={2013},
  volume={49 1},
  pages={
          143-50
        }
}
  • Angelia D. Lockett, Samuel T. Kimani, +4 authors Irina Petrache
  • Published in
    American journal of…
    2013
  • Biology, Medicine
  • α₁-Antitrypsin (A1AT) is an acute-phase reactant, but also a major protective factor against the development of chronic obstructive pulmonary disease, a complex disease with sustained chronic inflammation. The lung-protective effects of A1AT have been attributed to the inhibition of proteases involved in lung matrix fragmentation, macrophage activation, and endothelial-cell apoptosis. More recently, A1AT has been shown to directly interact with or modulate the actions of cytokines such as TNF… CONTINUE READING

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