α‐Glycerophosphocholine in the Mental Recovery of Cerebral Ischemic Attacks

@article{Sangiorgi1994GlycerophosphocholineIT,
  title={$\alpha$‐Glycerophosphocholine in the Mental Recovery of Cerebral Ischemic Attacks},
  author={Giuseppe Barbagallo Sangiorgi and Mario Barbagallo and Marcello Giordano and Maria Meli and Rita Panzarasa},
  journal={Annals of the New York Academy of Sciences},
  year={1994},
  volume={717}
}
The clinical efficacy and the tolerability of alpha-glycerophosphocholine (alpha-GPC), a drug able to provide high levels of choline for the nervous cells of the brain and to protect their cell walls, have been tested in a clinical open multicenter trial on 2044 patients suffering from recent stroke or transient ischemic attacks. alpha-GPC was administered after the attack at the daily dose of 1000 mg im for 28 days and orally at the dose of 400 mg tid during the following 5 months after the… 
Alpha-Glycerylphosphorylcholine Increases Motivation in Healthy Volunteers: A Single-Blind, Randomized, Placebo-Controlled Human Study
TLDR
The data suggest that αGPC can be used to increase motivation in healthy individuals and suggest thatαGPC treatment show a tendency to increased motivation during the intervention period.
Peripheral inflammatory activation after hippocampus irradiation in the rat
TLDR
Targeted brain irradiation produced measurable pro- and anti-inflammatory cytokine changes in the systemic circulation, and GPC supplementation provides significant protection against irradiation-induced peripheral pro-inflammatory activation and ATP depletion.
[Combined therapy of cerebrovascular disorders with neuroprotectors].
  • M. Putilina
  • Medicine, Psychology
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova
  • 2016
TLDR
Basing on the possible therapeutic interactions, 2-ethyl-6-methyl-3-hydroxypyridine succinate can be recommended as a basic medication for patients with cerebrovascular diseases to normalize the energy metabolism of brain cells.
Safety assessment of AGPC as a food ingredient.
  • A. Brownawell, E. Carmines, F. Montesano
  • Biology, Chemistry
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2011
l-Alpha-glycerylphosphorylcholine can be cytoprotective or cytotoxic in neonatal rat cardiac myocytes: a double-edged sword phenomenon
TLDR
The first evidence for the cytoprotective effect of short-term GPC treatment is provided, however, long-term administration of GPC may exert cytotoxicity in a wide concentration range in cardiac myocytes, which may draw attention to a comprehensive cardiac safety protocol for the testing of G PC.
Revisiting choline alphoscerate profile: a new, perspective, role in dementia?
  • P. Scapicchio
  • Biology, Psychology
    The International journal of neuroscience
  • 2013
TLDR
It is desirable to reconsider alpha-GPC in larger carefully controlled studies not only as monotherapy but also in association with cholinesterase inhibitor drugs.
The role of acetylcholine neurotransmission in the pharmacotherapy of cognitive dysfunction
TLDR
The article presents the materials of experimental and clinical studies of the drug choline alfostserat (Gliatilin) and takes a special place among the precursors of choline due to its proven effectiveness in the treatment of ischemic and neurodegenerative lesions of the central nervous system.
...
...

References

SHOWING 1-10 OF 10 REFERENCES
A Multicentre Trial to Evaluate the Efficacy and Tolerability of α-Glycerylphosphorylcholine versus Cytosine Diphosphocholine in Patients with Vascular Dementia
TLDR
The results suggest that in most tests α-GPC possessed a statistical higher efficacy and an overall more satisfactory activity assessed by both patients and investigators compared with CDP.
A controlled trial of nimodipine in acute ischemic stroke.
TLDR
The data suggest that patients with acute ischemic stroke may benefit from early treatment with nimodipine, but this therapeutic effect appears to be limited to men.
Effects of trifluoperazine on the central nervous system of the cat.
  • R. D. Hudson
  • Biology, Psychology
    International journal of neuropharmacology
  • 1966
Dementia in stroke survivors in the Stroke Data Bank cohort. Prevalence, incidence, risk factors, and computed tomographic findings.
TLDR
Prevalence of dementia was related to age but not to sex, race, handedness, educational level, or employment status before the stroke, and the most important predictors were a previous stroke and the presence of cortical atrophy at stroke onset.
Assessment of interobserver variability in a Dutch multicenter study on acute ischemic stroke.
TLDR
The interobserver agreement expressed in terms of kappa statistics is estimated for a multicenter study on acute ischemic stroke and it is advised that in the development of assessment scales, items with low interob server agreement should be avoided.
The Global Deterioration Scale for assessment of primary degenerative dementia.
TLDR
The authors describe a Global Deterioration Scale for the assessment of primary degenerative dementia and delineation of its stages and have used it successfully for more than 5 years and validated it against behavioral, neuroanatomic, and neurophysiologic measures in patients with primary degeneratives dementia.
ECDEU Assessment Manual for Psychopharmacology
  • 1976