αβ T Cell Receptor Mechanosensing Forces out Serial Engagement

@inproceedings{Feng2018TC,
  title={αβ T Cell Receptor Mechanosensing Forces out Serial
Engagement},
  author={Yinnian Feng and Ellis L. Reinherz and Matthew J Lang},
  booktitle={Trends in immunology},
  year={2018}
}
T lymphocytes use αβ T cell receptors (TCRs) to recognize sparse antigenic peptides bound to MHC molecules (pMHCs) arrayed on antigen-presenting cells (APCs). Contrary to conventional receptor-ligand associations exemplified by antigen-antibody interactions, forces play a crucial role in nonequilibrium mechanosensor-based T cell activation. Both T cell motility and local cytoskeleton machinery exert forces (i.e., generate loads) on TCR-pMHC bonds. We review biological features of the load… CONTINUE READING
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