αβγ-Synuclein triple knockout mice reveal age-dependent neuronal dysfunction.

@article{GretenHarrison2010SynucleinTK,
  title={αβγ-Synuclein triple knockout mice reveal age-dependent neuronal dysfunction.},
  author={Becket Greten-Harrison and Manuela Polydoro and Megumi Morimoto-Tomita and Ling Diao and Andrew Mark Williams and Esther H Nie and Sachin Makani and Ning Tian and Pablo E Castillo and Vladimir L Buchman and Sreeganga S Chandra},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 45},
  pages={19573-8}
}
Synucleins are a vertebrate-specific family of abundant neuronal proteins. They comprise three closely related members, α-, β-, and γ-synuclein. α-Synuclein has been the focus of intense attention since mutations in it were identified as a cause for familial Parkinson's disease. Despite their disease relevance, the normal physiological function of synucleins has remained elusive. To address this, we generated and characterized αβγ-synuclein knockout mice, which lack all members of this protein… CONTINUE READING