ΔNp73 stabilises TAp73 proteins but compromises their function due to inhibitory hetero-oligomer formation

Abstract

TP73 shares significant structural homology with TP53. This predicts functional similarities for the regulation of cell cycle and apoptosis. Indeed, TAp73 becomes transcriptionally activated upon DNA-damaging agents and oncogenes independent of p53 and ectopic TAp73 transactivates many p53 target genes involved in cell cycle arrest and apoptosis. Also… (More)
DOI: 10.1038/sj.cdd.4401335

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