ΔNp63 Controls a TLR3-Mediated Mechanism That Abundantly Provides Thymic Stromal Lymphopoietin in Atopic Dermatitis

@inproceedings{Kubo2014Np63CA,
  title={ΔNp63 Controls a TLR3-Mediated Mechanism That Abundantly Provides Thymic Stromal Lymphopoietin in Atopic Dermatitis},
  author={Terufumi Kubo and Ryuta Kamekura and Ayako Kumagai and Koji Kawata and Keiji Yamashita and Yukari Mitsuhashi and Takashi Kojima and Kotaro Sugimoto and Akihiro Yoneta and Yasuyuki Sumikawa and Toshiharu Yamashita and Noriyuki Sato and Tetsuo Himi and Shingo Ichimiya},
  booktitle={PloS one},
  year={2014}
}
In the skin lesions of atopic dermatitis (AD), keratinocytes release large quantities of thymic stromal lymphopoietin (TSLP), causing unfavorable inflammation along with skin damage. Nevertheless, how TSLP influences keratinocytes themselves is still unknown. In this study, we showed that ΔNp63, a p53-homologue, predominantly expressed in keratinocytes… CONTINUE READING