ΔF508 heterozygosity in cystic fibrosis and susceptibility to asthma

@article{Dahl1998F508HI,
  title={ΔF508 heterozygosity in cystic fibrosis and susceptibility to asthma},
  author={M. Dahl and A. Tyb{\ae}rg-Hansen and P. Lange and B. Nordestgaard},
  journal={The Lancet},
  year={1998},
  volume={351},
  pages={1911-1913}
}
  • M. Dahl, A. Tybærg-Hansen, +1 author B. Nordestgaard
  • Published 1998
  • Medicine
  • The Lancet
  • BACKGROUND Cystic fibrosis is a recessive disorder mainly characterised by lung disease. We tested the hypothesis that individuals heterozygous for the common cystic fibrosis deltaF508 mutation are at risk of obstructive pulmonary disease. METHODS We studied a cross-sectional sample from the general population of Copenhagen, Denmark, aged 20 years and older. We did spirometry to measure forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC), and did genotyping on blood samples… CONTINUE READING
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